Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th International Conference on Hypertension & Healthcare Scandic Jarvenpaa | Helsinki, Finland.

Day :

  • Clinical Cardiology| Cardiac Surgery | Rehabilitation of Cardiovascular Diseases and Healthcare | Interventional Cardiology | Cardiac Diseases | Hypertension & Heart Disease | Case Presentations | Hypertension Risk Factors
Location: Helsinki, Finland

Session Introduction

Simin Jafari

Islamic Azad University, Iran

Title: Effect of moderate physical activity on reduce of blood pressure in hypertensive patients

Time : 12:30-13:00

Biography:

Simin Jafari has completed her PhD in Sports Psychology from Imam Reza International University, Iran. She is currently working as a Sports Psychologist of Iran's Youth Rowing Team, Iran and also Instructor at Faculty of Physical Education and Sport Sciences, Islamic Azad University, Iran.

Abstract:

The purpose of this study was to measure the effects of moderate physical activity (60% of Maximal Heart Rate, MHR) on the reduction of blood pressure in elderly people with hypertension. Hypertension is considered a modifiable risk factor for cardiovascular disease through physical activity. The purpose and significance of this study, was to investigate the role of exercise as an alternative therapy, since some patients exhibit sensitivity/intolerance to some drugs. Initially, 30 hypertensive males (average age=46.7 years) were selected (systolic blood pressure, SBP>140 mmHg and/or diastolic blood pressure, DBP>90mmHg). The subjects were divided based on their age, duration of disease, physical activity and drug consumption. Then, blood pressure and Heart Rate (HR) were measured in all of the patients using sphygmomanometer (pre-test). The exercise session was consisted of warm up, aerobic activity and cool down (total duration 45 minutes). At end of the session, blood pressure measured for the second time (post-test). The results were analyzed using t-test. Our results indicated that moderate physical activity was effective in lowering blood pressure by 7.16 mmHg for SBP and 4.93 mmHg for DBP in hypertensive patients, irrespective of age, duration of disease, physical activity and drug consumption (p<0.05). Physical activity programs with moderate intensity (approximately at 60% MHR), four days per week can be used not only as a preventive measure for diastolic hypertension (DBP>90 mmHg high blood pressure), but as an alternative to drug therapy in the treatment of hypertension, as well. Aerobic exercise is able to produce reductions in hypertensive patients. Recent findings suggest that a modification of dietary and fitness habits are helpful in the prevention or the control of high blood pressure. Previous studies showed that patients with hypertension managed to reduce their blood pressure by about 6-10 mmHg through physical activity. These results are similar to the reductions achieved in the current study. Applications of this study are simple and useful for prevention and treatment of hypertension.
 

Maria Dorobantu

Carol Davila University of Medicine and Pharmacy, Romania

Title: Limits of pharmacological treatment in heart failure

Time : 14:00-14:45

Biography:

Maria Dorobantu has worked as senior specialist in internal medicine and Senior specialist in cardiology during 1990-1996. She is Director of the Research Center of Excellency for the diagnosis and treatment of cardiovascular emergencies and she is Director of Hypertension Center of Excellence, European Society of Hypertension. She is Initiator and Coordinator for National Studys SEPHAR (I-III). She is reviewer for multiple journals viz., American Heart Journal, Cor et Vasa, Journal of Hypertension, PLOS ONE.

Abstract:

Heart failure (HF) is the most common and deadliest syndrome in contemporary Cardiology. A poor prognosis, frequent re-hospitalizations and decreased quality of life is sadly still characterizing the patient with heart failure. Despite major advances in pharmacological and interventional treatment, heart failure remains a major health problem in all European countries. With a prevalence between 4,4% - 7% and an incidence between 2,5‰ - 44‰, HF tends to progress with the aging. If today there are estimated 15M patients with HF in Europe, by 2030 this number is expected to double. Main objectives of pharmacological treatment in heart failure are represented by: prevention of myocardial damage through optimal management of diseases that cause HF (coronary artery disease, valvular diseases, hypertension), preventing and slowing the ventricular remodeling process, treatemnt of associated comorbidities (such as diabetes mellitus, chronic kidney disease, atrial fibrilation, iron deficiency, etc), reduction of morbi-mortality, decreasing the number of re-admisions due to acute worsening of HF and improuvment of clinical status, functional capacity and quality of life of patients with HF. The pharmacological treatment in HF with reduce LV ejection fraction is targeting the neuro hormonal systems involved in development and progression of this condition: the over activation of sympathetic nervous system (SNS), of renin-angiotensin-aldosteron system (RAAS) and the natriureticpeptide system. While the over-activation of SNS is well documented in HF patients, beta-blockers (BB) represent one of the first-line HF treatment. The effects of BB are: reduction of heart rate and oxygen demand, beta-receptors modulation, reduction is RAAS activation, a protective effect by reducing catecholamine spillover toxicity, anti-ischemic and anti-arrhytmic effects, antioxidant and antiinflamatory effects, improuving miocardial protein sintesis and promoting peripherral vasodilation. The over-all effect of BB treatment leads to decreased morbi-mortality, decreased re-hospitalization and improvement of clinical symptoms in patients with HF. But not all BB have all these benefical effects, so we need to emphasise that these effects are not a class effects. Only 3 BB have evidence of decreasing mortality in HF patients: bisoprolol, succinate-metoprolol, carvedilol, while nebivolol did not decreed mortality in elderly patinets, but only CV death and re-hospitalization rate. A major step in the pahrmacological treatment of patients with HF was represented by RAAS blockage with angiotensin converting enzyme inhibitors (ACEIs) which brought a reduction in mortality by 20-25%, decreased the number of rehospitalizations by 30-35%, prevent LV remodeling, decrease LV pre and afterload, stabilizes atherosclerotic plaques reducing the risk of ACS, have renoprotetiv effects (preventing renal failure and proteinuria) and decreases the risk of DM on-set. The RAAS blockade by of angiotensin receptor blockers (ARBs) have limited evidence compared to ACEIs, being recommended to be used only as an alternative to ACEIs- intolerant patients. That is why current guidelines recommend BB+ ACEIs (or ARBs to ACEIs intolerant patients) as the core-stone of phamacological treatment in HF patients. However, in HF patients receiving BB+ ACEIs/ ARBs, re-hospitalization rate at 3 months is 30% and 5-year death-rate is 50%. In HF patients aldosterone levels are increased by 20 times, since there is an independent ATII production from the endothelial cells and smooth-muscle cells of blood vessels and heart. That is why is use of mineralocorticoidreceptor blockers antagonists (MRAs) have antifibrotic effect and cardiac and vascular level, decrease miocites hypertrophy and apoptosis, decrease inflammation and calcifications and also decrease Na and water retention, K and Mg excretion. In RALES and EMPHASIS trails, the use of MRAs spiroloactone has proved reduction of morbi-mortality in patients with severe HF. If HF patients remain symptomatic after up-titration to maximum tolerate evidence-base dose of BB+ ACEIs/ ARBs, the current guideline recommend to add an MRA that up be up-titrated also to to maximum tolerate evidence-base dose. If the patients is still symptomatic and able to tolerate ACEIS (or ARBs) than the guideline recomend to replace ACEIs (or ARBs) with angiotensin-receptor neprilisin inhibitor (ARNI). The natriuretic-peptide system includes 3 structurally simmilar peptides which exerts protective cardio-renale effects (atrial natriuretic peptide (ANP), B-type natriuretic peptide and C-type natriuretic peptide), which practically antagonizes the effects of RAAS over-activation. The inactivation of the natriuretic peptides is accomplished by hydrolysis under the action of neprilinsin, a reactive endopeptidase which is responsible for inactivation of several endogenous vasoactive peptides. Thus, the use of a neprilisin- inhibitor in patients with heart failure is obvious: increasing circulating levels of mature natriuretic peptides capable of exerting hemodynamic, natriuretic and diuretic effects. This combination - ARNI: dual inhibitor of angiotensin type 1 receptor and neprilisine (LCZ696: valsartan+sacubritril, 400 mg / day) was recently tested in comparison with ACEIs (enalapril 20 mg/day) in PARADGM-HF trail. After a median follow-up period of 27 months, the study was prematurely stopped due to the overwhelming superiority of LCZ696 treatment to enalapril, reducing the primary endpoint (risk of cardiovascular death with a risk of respiratory failure) by 20% and a total mortality of 16%. Other pharmacological options for patients with HF with reduced EF which remains symptomatic despite treatment with evidence-base dose of BB, ACEIs (or ARBs) and MRAs are represented by: • Ivabradine – recommended if patients are in sinus rhythm with a HR>70bpm • Hidralasine and isosorbid dinitrat – recommended as alternative to ACEIs/ ARBs if neither is tolerated, or if the patient remains symptomatic despite treatment BB, ACEIs (or ARBs) and MRAs • Digoxin – recommended if patients associated atrial fibrillation of flutter with increased ventricular response, or if the patient is in synus rhythm bur intolerant to BB, or remains symptomatic despite treatment BB, ACEIs (or ARBs) and MRAs • Nutritional supply by Q10-coenzyme, B1 vitamin, carnitine and taurine. The diuretic treatment in patients with HF is only recommended for congestive symptoms relieve and maintain euvolemia. While the pharmacological arsenal of HF with reduced LVEF is nowadays vast, in patients with HF with preserved or mid-range LVEF no treatment has proved reduction in mortality or morbidity. IN this patients diuretic treatment is recommended for symptom relieve, treatment of associated co-morbidities (HT, CAD, AF, etc). In conclusion, the pharmacological treatment available today has improved the morbi-mortality and functional capacity of HF patients, but due to its inherent limits, a significant proportion of patients remain symptomatic with frequent re-hospitalizations, an limited functional capacity and still a high mortality rate

Oana Gheorghe Fronea

Carol Davila University of Medicine and Pharmacy, Romania

Title: New era in HF treatment-Medical management

Time : 14:45-15:30

Biography:

Oana Gheorghe-Fronea is Head of the department in Carol Davila University of Medicine and Pharmacy.
 

Abstract:

We present a case of a 35-year-old female who presented to the emergency room with severe dyspnea with orthopnea and angina she denied any personal or family history of cardiovascular disease, but reported two recent episodes of pneumonia for which she received empirical antibiotic treatment with Cefuroxime and Clarithromycin. Physical examination revealed an overweight patient, mild bibasilar crackles and systolic cardiac murmur over the mitral area. Her blood pressure was 190/100 mmHg and heart rate 120 BPM. Initial laboratory data showed elevated CK-MB and NT-proBNP, elevated liver enzymes and normal renal function. There were no particular findings on the surface ECG. The echocardiography revealed a dilated Left Ventricle (LV), severe systolic dysfunction (ejection fraction 20%) due to global hypokinesia, intraventricular dyssynchrony despite a narrow QRS complex on the surface ECG and moderate secondary mitral regurgitation. In this context, the optimal treatment for heart failure with reduced ejection fraction was initiated (at first perindopril then combination Sacubitril-Valsartan, Spironolactone, Furosemide, Metoprolol). On follow-up echocardiographic examinations, the ejection fraction gradually increased up to 45% at eight months examination.  To clarify the cause of chamber dilation, a CMR was pursued which confirmed both left and Right Ventricle (RV) dilation (LV 171 ml/m2, RV 136 ml/m2) and severe systolic dysfunction. In addition, no edema or areas of focal myocardial fibrosis were noticed. The apical region of the LV was hypertrabeculated with a non-compacted/compacted myocardium radio of 2.2 in long axis views suggestive of non-compaction. No thrombus was seen. Also, we excluded an ischemic etiology considering the absence of coronary lesions, the diffuse hypokinesia on echocardiography and the lack of ischemic changes on CMR. In addition, acute myocarditis was unlikely due to the non-suggestive CMR aspect. Finally, the 24-hour ECG monitoring showed very rare ventricular extrasystoles accounting for only 0.5% of total ventricular beats and no tachyarrhythmia, making a diagnosis of tachycardiomyopathies improbable. In conclusion, myocardial non-compaction may be the expression of a genetic cardiomyopathy or may be the phenotypic appearance of other causes of left ventricle dysfunction. The reversibility of the disease in our patient does not support the diagnosis of genetic non-compaction cardiomyopathy. The patient was nonetheless programmed for genetic testing given the psychological burden that this diagnosis implies. So far, we were not able to determine a trigger for the reversible ventricular dysfunction in this patient. A question remains whether the optimal medical treatment for heart failure with reduced ejection fraction could nowadays completely reverse even a genetic form of non-compaction

Corneliu Iorgulescu

Inter Cardio Clinique, Romania

Title: Interventional management in a heart failure patient

Time : 15:45-16:30

Biography:

Career Performance Professional Training: - Graduate of UMF Carol Davila Bucharest 2003 - Cardiology Specialist 2010 -Examen European Competence of Implantable Cardiac Devices 2008 -Examen European Electrophysiology Competence 2012 - Europhysiology Training Course 2011-2012 in Hungary, Szeged - Romanian Society of Cardiology extraction of implantable cardiac devices in Italy, Pisa - 2016 Performed procedures: - Cardiac simulators - Resynchronization therapy - Cardiac defibrillators - Standard radiofrequency abrasions - 3D assisted radiofrequency assemblies - Implanted cardiac extractions

Abstract:

We present the case of 72 years male; diabetic, hypertensive with ischemic cardiomyopathy, moderate-severe mitral regurgitation and left bundle branch block. At the initial hospitalization the patient had a 25% LVEF and was NYHA 4 with optimal medical therapy- ACE inhibitor, Beta-blocker, Spironolactone and Furosemide. He had trivascular coronary heart disease with complete interventional revascularization. A CRT-D was implanted with an increase of LVEF at 35% to 40% at six months and NYHA class II symptoms. After two years he developed atrial fibrillation and NYHA class III symptoms. Amiodarone was attempted unsuccessfully so after six months a pulmonary veins isolation procedure was performed. The patient remained in sinus rhythm and NYHA II for one year than atrial fibrillation reoccurred. At that moment he was NYHA III with optimal medical therapy, LVEF was 35% with severe mitral regurgitation. The patient was proposed for mitral clip implant and he was switched to Sacubitril/Valsartan therapy. He improved to NYHA II class and remained stable for two years. No mitral clip was implanted. 

F. R. den Hartog

Gelderse Vallei Hospital, Netherlands

Title: Atrial fibrillation and heart failure: Focus on NOACs

Time : 16:30-17:15

Biography:

FR den Hartog is trained as a cardiologist in the Onze Lieve Vrouw Gasthuis (OLVG) in Amsterdam. He then worked as a cardiologist in Rotterdam. In 1989 he started at the Gelderse Vallei Hospital. From Rotterdam, he introduced cardio-vascular research in the Gelderse Vallei Hospital. Currently, this has grown into a large department of cardiovascular research, which participates in many international studies. For this, this department works together with many cardiology clinics in the Netherlands. Special interest exists in lipid (cholesterol) disorders, heart failure, and atrial fibrillation. He is also medical manager of the cardiology department

Abstract:

  • Clinical Cardiology| Neonatal Cardiology | Cardiac Nursing | Hypertension | Heart Failure | Echocardiography | Clinical Case Reports on Cardiology | Hypertension & Heart Disease | Echocardiography & Cardiac Imaging | Renal Hypertension| Hypertension Diagnosis
Location: Helsinki, Finland

Session Introduction

Mehdi Kasbparast Jui Ray

Islamic Azad University, Iran

Title: Effect of bodypump exercise on adiponectin serum level among sedentary obese female

Time : 11:30-12:00

Biography:

Mehdi Kasbparast Jui Ray is faculty member of Physical Education and Sport Sciences, Karaj branch, Islamic Azad University, Karaj and he is doctoral student in sport injury and member of Asian Society for physical Education and Sport for 15 years

Abstract:

The prevalence of obesity and its complications is rapidly increasing worldwide. Body pump was created as a muscular endurance workout based on scientific research. The purpose of the present study was to determine of body pump exercise effect on adiponectin serum level in sedentary obese females. First of all randomly selected 22 untrained females with average age 25.36±7.50 years old, weight 91.15±13.12 kg, height 164.09±5.92 cm and body mass index (BMI) 33.95±5.95 kg/m² (experimental group) and 20 untrained females with average age 30.63 ±6.39 years old, weight 85.35±10.65 kg, height 163.55±5.72 cm and body mass index (BMI) 31.92±2.95 kg/m² (control group) who had no exercise training in last one year. The study method was semi-experimental research. In this study experimental group done body pump training with a progressive resistance training protocol (included 8 resistance training, 3 sessions per week, for totally 6 weeks) and the control group did not any training during protocol training time. Blood samples were collected after 12- 14 hour fasting in the same conditions at the beginning of program and at the end of 6th week of performance (per- test and post- test sample). Pre- test and post- test serum adiponectin values were measured. We used kolmogorov-smirnov statistical tests to analyse the results and dependent t- test to comparison of pre- test and post- test variables. The all calculations were accomplished by SPSS software, version.19. The results indicated that the body pump training on adiponectin volume in experimental group had no significant difference (p>0.05

Biography:

Susan Fletcher has worked as a Counsellor, Social Worker, Lecturer and Researcher in both Hospital and Educational Institutions. Her Expertise is in evaluation of effective service delivery and behavioral change interventions for people with chronic cardiac health conditions.
 

Abstract:

Purpose: There has been extensive investigation of attendance rates at Cardiac Rehabilitation (CR) but little attention to client reasoning around attendance. This study explored participants’ decision-making drivers for attendance or non-attendance at CR programs available in rural Victoria, Australia. Method: All new patients referred to the CR programs at either the local hospital or community health service over a six months period were invited to participate and were interviewed before, after and at six months post CR. Content analysis was used to identify and group common themes that emerged from the semi-structured interviews. Results: Eighty-four of the 114 patients referred agreed to participate in the study. Multiple barriers or facilitators affected the decisions of all clients. Two main themes emerged; The first theme described the participant decision-making experience, the invitation and information about participation in CR and identified the need for a person centered approach to CR provision and on-going support. The second theme identified significant decision-making points: Following the cardiac event; before and after hospital-based CR; before and after community-based CR and at six months post the cardiac event. At any time, there is a risk that the client can become lost or disengaged in the service system but providing contact at these points can facilitate re-engagement. Conclusion: This study provided the opportunity to hear participants’ voices describing their decisions around CR attendance after a cardiac event and their ability to sustain lifestyle behavioral change. They highlighted the complexity of issues confronting them and suggested improvements to optimize their attendance and to maintain lifestyle changes.
 

Naseer Ahmed

Bright Future College of Nursing and Allied Health Sciences, Pakistan

Title: A cross sectional research study of blue-collar worker’s health in relation to their life style and cardiovascular diseases

Time : 12:30-13:00

Biography:

Naseer Ahmed is currently working as the Principal and Faculty of Public Health at Bright Future College of Nursing and Allied Health Sciences.

Abstract:

According to World Health Organization, the cardiovascular disease was the leading cause of NCD (Non-communicable diseases) deaths in 2012 and was responsible for 17.5 million deaths or 46% of NCD-caused deaths. The purpose of this study to signify a key in the development of an area of research by identifying the importance of cardiovascular disease among blue-collar workers and timely measure for maintenance of their better health status. Using a cross-sectional research analysis, this study analyzed the incidence of cardiovascular disease among blue-collar workers. Prevalence of cardiovascular disease was proven to be relatively high. However, the awareness treatment and the control of cardiovascular disease in this population were very low; the prevalence was higher in Indians compared to Pakistani and Bangladeshi or other nationalities. Risks were higher among those who were having the smoking habit or high cholesterol food intake. Also and the majority was married, overweight or obese. It is hoped this study will contributes to the information on the issue and possibly adds some useful information for policy makers and blue-collar workers (industrial or occupational workers) about management practices of good cardiovascular health. This study clearly answers (addresses) the question why blue-collar workers are having more cardiovascular diseases then white-collar workers and further more studies are require to discuss this issue world-wide. Human resources development is one of the main fields which require attention in successful organizations. Blue-collar workers are the backbone on any country's economy; to get powerful economy of the country therefore it is very necessary to look for the blue-collar workers’ health. According to the World Health Organization (WHO), non-communicable diseases such as cardiovascular disease, cancer, chronic respiratory disease and diabetes cause 60% of all deaths globally, 80% of this mortality occurs in low and middle income countries. Dubai’s labor force depends on these low middle income countries like India, Pakistan, Bangladesh and other South Asian countries. In this population cardiovascular diseases are very common due to many reasons like there is no check and balance on governmental healthcare facilities, financial issues and health education etc. Ignorance of these life threatening conditions leading them to carry this burden till they end up in hospitals. If blue-collar workers would be fit physically and mentally then the result would be in the form of powerful economy and booming industrial zones. This research teaches us many facts regarding medical and social aspects of the life of blue-collar workers and just little help and care can save many lives of this very important community called blue collar-workers. This study clearly answers the question why blue-collar workers are having more cardiovascular diseases then white-collar workers and further more studies are require to discuss this issue world-wide.
 

Hossein Tabriziani

Balboa Institute of Transplantation, USA

Title: Kidney transplant and improve cardiovascular outcomes

Time : 14:00-15:00

Biography:

Tabriziani has earned his MD with honors from Iran University of Medical Sciences (IUMS). He finished his Internal Medicine residency at St. Barnabas Hospital, Weill Cornell Medical College in New York. With passion for education and Transplantation, he accepted the fellowship in Nehrology and Hypertension at Georgetown University in Washington, DC and continued his education at University of California San Francisco (UCSF) with a Transplant Nephrology fellowship. He was appointed at the Medical director of Pancreas Transplantation at Westchester Medical Center, New York Medical college before moving to Loma Linda University in California to serve as an Assistant Professor of Medicine in Nephrology / Transplant division. He is an active member of American Society of Nephrology and American society of Transplantation. His interests are in Hypertension and Oxidative Stress in patients with chronic kidney disease and transplantation.

Abstract:

The prevalence of kidney disease and End Stage Renal Disease (ESRD) continues to rise in the world. By the year 2030, the number of patients with ESRD in USA is projected to exceed 2.2 million. This is more than five times the current prevalence. During the past decade, kidney transplantation has increasingly been recognized as the treatment of choice for medically suitable patients with ESRD. As well as improving quality of life, successful transplantation confers major benefits by improving morbidity and mortality of ESRD patients who receive kidney transplant over those who undergo Renal Replacement Therapy (RRT). Cardiovascular (CV) risk reduction remains the leading cause of this improvement. There are many reasons for this drastic success in reduction of CV death. Higher Glomerular Filtration rate (GFR) usually result in lower incidence of high blood pressure. Many kidney transplant recipients are experiencing a significant improvement in blood pressure control with fewer medications within months of surgery. Oxidative stress also plays a key role in the pathophysiological process of uremia and its complications, particularly in cardiovascular disease. The level of oxidative stress markers is known to increase as Chronic Kidney Disease (CKD) progresses and correlates significantly with level of renal function. Successful kidney transplantation results in near normalization of the antioxidant status and lipid metabolism by eliminating free radicals despite the surge of oxidative stress caused by the surgical procedure and ischemic injury to the organ during the operation. This success is associated with both improved renal functions, reduced cardiovascular complications and overall improved morbidity and mortality.

Biography:

Sudaporn Khosuk is the student of Master of Science, School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University

Abstract:

Increase of systolic blood pressure difference between arms was associated with increased risk of atherosclerosis and also identified as a predictor of cardiovascular event and mortality. The aim of this study was to investigate the prevalence of an inter-arm systolic blood pressure difference (sIAD) in hypertensive elderly and to identifity what factors include participant’s characteristic and physical performance between individual who have normal and abnormal sIAD, who living at Yasothon province, Thailand. This study was conducted  cross sectional study from review medical data and selected 196 hypertensive elderly without cardiovascular disease and who met inclusion criteria (average age 71.74 ± 6.58 years, 54.08% women, 68.37% never smoked). Blood pressure was recorded randomly sequential technique for each arm using an automated oscillometric device. The sIAD was expressed as the absolute systolic blood pressure, and difference were determined for individual subject, was calculated by subtracting the right arm systolic blood pressure (R) from the left arm (L) (|R-L|). Participants were evaluated vascular status by sIAD and physical performance was assessment by hand grip strength. The prevalence of an abnormal sIAD will report as a percentage and compared the between group was used Student t-test, differences were considered to be statistically significant where p < 0.05.  The prevalence of abnormal sIAD (defined as sIAD ≥ 10 mmHg) was 17 (8.67%) participants. Number of participant who reported smoke habit (ex-smoker and current smoker) together with resting systolic blood pressure were significantly higher in participants who had abnormal sIAD group (p < 0.05). The results instruct there is considerable that abnormal sIAD in the hypertensive elderly, which was risk factor for cardiovascular disease. Thus, in primary care may applied blood pressure measurement as a simple tool for assessment of cardiovascular status in Thai community population